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Sources: Regarding Tesofensine and Dihexa, and their comparison based on Cmax, several points were mentioned on the Mind Pump Podcast: Tesofensine : It was noted for its strong effects on increasing brain-derived neurotrophic factors (BDNF), enhancing focus, and well-being

Endothelial dysfunction is improved by inhibition of the Rho/ROCK (Rho-Kinase) pathway, leading to increased NO production, while antithrombotic properties such as atherosclerotic plaque stabilization are also attributed to this drug class

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3a) and NADH levels elevated as well but showed large inter-individual differences (Fig

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